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September 10, 2025ACS OmegaOpen Access

Benzimidazole-Coordinated Copper(II) Complexes as Effectual Chemotherapeutics against Malignancy

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Authors

ASAnkita SahaUniversity of Engineering & ManagementADAnanya DebnathInstitute of Catalysis and PetrochemistryMCM.K. ChettriInstitute of Catalysis and Petrochemistry

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Overview

Benzimidazole-based copper(II) complexes enhance cytotoxicity in cancer cells, suggesting novel treatment options.

Key Points

  • Both copper(II) complexes displayed significant cytotoxicity against various cancer cell lines, indicating potential as effective treatments.
  • Molecular docking studies reveal stable binding conformations with crucial proteins like p53, BAX, and BCL2.
  • The synthesis and structural characterization of the complexes highlight their stability and geometrical arrangements.
  • Cell cycle and apoptosis assays confirm that these complexes induce apoptosis in tumor cells, showing promise for overcoming drug resistance.

Cite This Study

Saha et al. (2025) studied this question.

synapsesocial.com/papers/68c1a5e554b1d3bfb60df14bhttps://doi.org/10.1021/acsomega.5c02269
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