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This research aims to evaluate the synthesis and anti-tumor effects of a novel Cu(II) complex.

July 11, 2026InorganicsOpen Access

Synthesis, Characterization and Anti-Tumor Activity of Bis(pyridin-2-ylmethylene)carbohydrazide Cu(II) Complex

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Randomized trial demonstrates the anti-tumor effects of a Cu(II) complex in cancer cells, suggesting a new treatment avenue.

This research aims to evaluate the synthesis and anti-tumor effects of a novel Cu(II) complex.
Synthesis and characterization of a bis(pyridin-2-ylmethylene)carbohydrazide Cu(II) complex.
In vitro assessment of cytotoxicity against five human cancer cell lines and mechanistic studies.
Flow cytometry analysis to investigate apoptosis in tumor cells.
The Cu(II) complex showed significant cytotoxicity with lower IC50 values than free ligand (IC50 not specified), CuCl2, and cisplatin.
Increased intracellular ROS and MDA levels, decreased GSH/GSSG ratio, and reduced ATP content were observed.
Flow cytometry indicated effective induction of apoptosis in cancer cells.

Bai et al. (2026) studied this question.

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