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September 5, 2025Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca

Intra-Articular Use of Hyaluronic Acid Preparations in the Treatment of Knee Osteoarthritis

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Authors

MTMustafa TuranJGJiří Gallo

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Overview

Randomized clinical trials contrast intra-articular hyaluronic acid with PRP and corticosteroids in knee osteoarthritis, suggesting various benefits.

Key Points

  • Hyaluronic acid treatment shows moderate relief in knee osteoarthritis symptoms at six months post-administration.
  • Platelet-rich plasma injections provided the greatest effect and longevity of symptom relief compared to corticosteroids and hyaluronic acid.
  • Corticosteroid administration offers rapid pain relief, but effects diminish significantly after one month following treatment.
  • Previous guidelines from the ACR and NICE express caution regarding the use of hyaluronic acid in knee osteoarthritis management.

Cite This Study

Turan et al. (2025) studied this question.

synapsesocial.com/papers/68bb3d5b2b87ece8dc956253https://doi.org/10.55095/achot2024/065
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Advances in hyaluronic acid therapy for knee osteoarthritis: monotherapy and combination strategies: an evidenced based review2026 · 5 citations
  2. 2The efficacy and safety of platelet rich plasma and hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis2026 · 1 citations
  3. 3Comparative efficacy of ultrasound-guided intra-articular injection of platelet-rich plasma (PRP), hydrolyzed type I collagen, and hyaluronic acid in patients with knee osteoarthritis: a randomized controlled trial2026
  4. 4The Effectiveness Of Intra-Articular Hyaluronic Acid Injection Combined With Oral Nonsteroidal Anti-Inflammatory Drugs In The Treatment Of Knee Osteoarthritis2025
  5. 5Analogies Between Platelet-Rich Plasma Versus Hyaluronic Acid Intra-articular Injections in the Treatment of Advanced Knee Arthritis: A Single-Center Study2024 · 3 citations