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September 5, 2025International Journal of Molecular SciencesOpen Access

Tibolone Improves Motor Recovery and Regulates Neuroinflammation and Gliosis in a Model of Traumatic Spinal Cord Injury

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Authors

XFXimena Freyermuth-TrujilloSSStephanie Sánchez‐TorresCOCarlos E. Orozco-Barrios

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Overview

Observational analysis shows tibolone reduces neuroinflammation and gliosis in spinal cord injury, suggesting potential therapeutic benefits.

Key Points

  • Tibolone improved motor recovery after spinal cord injury by reducing gliosis and regulating inflammation.
  • Pro-inflammatory and anti-inflammatory cytokine levels were quantified at key time points, including 3, 7, and 14 days post-injury.
  • Immunohistochemistry showed reduced expression of gliosis markers in the tibolone-treated group, indicating enhanced tissue preservation.
  • These findings suggest synthetic steroids like tibolone could be beneficial for spinal cord injury recovery.

Cite This Study

Freyermuth-Trujillo et al. (2025) studied this question.

synapsesocial.com/papers/68bb3d5b2b87ece8dc956373https://doi.org/10.3390/ijms26178327
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tibolone Administration Is Associated with Enhanced Motor Recovery and Decreased Cell-Specific NOX2 and NOX4 Immunoreactivity in a Rat Model of Traumatic Spinal Cord Injury2026
  2. 2Tanshinone IIA Regulate Inflammatory Response and Promote Functional Recovery in Rats with Spinal Cord Injury2024 · 1 citations
  3. 3Attenuation of Transforming Growth Factor‐β Signaling Promotes Complete Recovery of Trabecular Bone Structure Following Immobilization With Traumatic Spinal Cord Injury2026
  4. 4Anti-Inflammatory Therapeutic Effect of Tegoprazan in Spinal Cord-Injured Rats2026
  5. 5Regulation of microglial polarization via notch signaling pathway by intrathecal administration of tanshinone IIA-PLGA sustained-release microspheres to promote neurological recovery after spinal cord injury2026