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September 5, 2025International Journal of Molecular SciencesOpen Access

Tibolone Improves Motor Recovery and Regulates Neuroinflammation and Gliosis in a Model of Traumatic Spinal Cord Injury

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Authors

XFXimena Freyermuth-TrujilloSSStephanie Sánchez‐TorresCOCarlos E. Orozco-Barrios

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Overview

Observational analysis shows tibolone reduces neuroinflammation and gliosis in spinal cord injury, suggesting potential therapeutic benefits.

Key Points

  • Tibolone improved motor recovery after spinal cord injury by reducing gliosis and regulating inflammation.
  • Pro-inflammatory and anti-inflammatory cytokine levels were quantified at key time points, including 3, 7, and 14 days post-injury.
  • Immunohistochemistry showed reduced expression of gliosis markers in the tibolone-treated group, indicating enhanced tissue preservation.
  • These findings suggest synthetic steroids like tibolone could be beneficial for spinal cord injury recovery.

Cite This Study

Freyermuth-Trujillo et al. (2025) studied this question.

synapsesocial.com/papers/68bb3d5b2b87ece8dc956373https://doi.org/10.3390/ijms26178327
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