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March 22, 2026Discovery Medicine

Anti-Inflammatory Therapeutic Effect of Tegoprazan in Spinal Cord-Injured Rats

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Authors

MKMin Je KimSKSeong Jun KimDLDaye Lee

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Overview

Evaluates tegoprazan's impact on inflammation and motor recovery in spinal cord-injured rats, suggesting therapeutic potential.

Key Points

  • To assess the therapeutic effects of tegoprazan on inflammation and recovery in a spinal cord injury model in rats.
  • Conducted spinal cord injury in female rats.
  • Administered tegoprazan intraperitoneally and compared with methylprednisolone.
  • Monitored body weight for toxicity assessment and performed behavioral tests for motor recovery.
  • Utilized immunofluorescence and qRT-PCR to assess inflammatory markers.
  • Analyzed MAPK and NF-κB signaling pathways with Western blot.
  • TEGO treatment did not show systemic toxicity and improved motor recovery.
  • TEGO and MP significantly reduced inducible nitric oxide synthase (iNOS) expression.
  • CD206 expression increased significantly in the MP group compared to the Vehicle group; TEGO showed a slight increase.
  • TEGO inhibited MAPK/NF-κB signaling pathways, reducing pro-inflammatory cytokine production.

Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/69bf8641f665edcd009e8bf3https://doi.org/10.24976/discov.med.202638206.57
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