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September 5, 2025ChemistrySelect

Synthesis of Dialdehyde Chitosan‐Based Schiff Base Polymeric Complexes for the Controlled Delivery of 5‐Fluorouracil (5‐FU) in Skin Cancer

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Authors

RKRamesh A. KasarSDSwati DubeySPS. K. Patel

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Overview

The development of a schiff base polymeric complex enabled efficient delivery of 5-fluorouracil in skin cancer, suggesting improved therapeutic outcomes.

Key Points

  • The hydrogel formulation showed a cumulative release rate of 98.34% for 5-fluorouracil in buffer solutions over 12 hours.
  • In vitro cytotoxicity tests on B16F10 skin cancer cells demonstrated significant anticancer efficacy for the developed hydrogel.
  • X-ray diffraction and FTIR analyses confirmed the compatibility of 5-fluorouracil with the polymer components, indicating stable formulation.
  • The synthesized dialdehyde chitosan served as an effective cross-linker, enhancing the properties of the hydrogel.

Cite This Study

Kasar et al. (2025) studied this question.

synapsesocial.com/papers/68bb3d682b87ece8dc956935https://doi.org/10.1002/slct.202501338
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An Overview of Biopolymers for Drug Delivery Applications2024 · 93 citations
  2. 2Chitosan: An Overview of Its Properties and Applications2021 · 1,737 citations