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June 13, 2026PLoS ONEOpen Access

Formulation of 5-fluorouracil loaded chitosan-based nanoparticles and evaluation of its cytotoxic effects against MCF-7 human breast cancer cells

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Authors

IEIdongesit Aniekan EkpoAOAiremwen Collins OvenseriAAAbdulrahman Abdullateef

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Overview

Randomized trial demonstrates cytotoxic effects of 5-fluorouracil nanoparticles in breast cancer cells, indicating potential for improved treatment outcomes.

Key Points

  • The research aims to develop chitosan-based nanoparticles loaded with 5-fluorouracil to enhance drug delivery and cytotoxic effects.
  • Formulated 5-fluorouracil nanoparticles using ionic gelation technique.
  • Characterized nanoparticles with UV spectrophotometry, FTIR, XRD, and SEM.
  • Evaluated cytotoxic effects on MCF-7 breast cancer cells through MTT assays.
  • 5-FU nanoparticles demonstrated a mean particle size of 218.62 nm with a zeta potential of ≤+32.18 mV.
  • Cytotoxicity assays revealed a time-dependent effect on MCF-7 cells after 72 hours, enhancing drug delivery efficiency with minimized side effects.
  • Drug release mechanism followed Fickian diffusion, supporting sustained release of the drug.

Cite This Study

Ekpo et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf62dfaef96ed7f05806bhttps://doi.org/10.1371/journal.pone.0350929
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