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September 5, 2025Analytical Chemistry

Self-Enhanced Ratiometric ECL Strategy Based on a Dual-Emission Ce/Tb-MOF Luminophore with Spatially Resolved Coreactant Delivery for Ultrasensitive Pro-GRP Detection

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Authors

DYDewen YanYZYue ZhangWGWeiming Gong

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Overview

Innovative dual-signal detection method improves Pro-GRP accuracy in clinical diagnostics, suggesting effective monitoring.

Key Points

  • The developed ECL immunosensor achieved a detection limit of 52.4 fg/mL, ensuring high sensitivity for Pro-GRP detection.
  • Using a dual-ligand Ce/Tb-MOF luminophore, the system effectively regulates signals to enhance detection accuracy in clinical settings.
  • The sensor displayed an extensive dynamic range from 100 fg/mL to 100 ng/mL, making it suitable for diverse clinical samples.
  • This study proposes a simplified and robust ECL platform design, emphasizing the utility of MOF-based biosensors in diagnostics.

Cite This Study

Yan et al. (2025) studied this question.

synapsesocial.com/papers/68bb3d682b87ece8dc9569c3https://doi.org/10.1021/acs.analchem.5c04144
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