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March 18, 2026Analytical Chemistry

Covalent Bridging Achieves Nanorestriction Enhanced Aggregation-Induced Electrochemiluminescence for 17β-Estradiol ECL Imaging-Assisted Dual-Mode ECL/EC Detection

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Authors

HGHao GengYLYuan LiZRZhuangzhuang Ru

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Overview

Novel dual-mode biosensor achieves ultrasensitive detection of 17β-estradiol, suggesting a breakthrough in monitoring techniques.

Key Points

  • To develop a dual-mode biosensor for the ultrasensitive detection of 17β-estradiol (E2) using ECL and EC techniques.
  • Integrated electrochemiluminescence and electrochemical detection techniques
  • Employed TCBPE-UiO-66-NH2 as the ECL emitter
  • Utilized Mg2+-driven DNAzyme walkers for signal amplification
  • Implemented an 'on-off-on' sensing strategy based on energy transfer
  • Applied ECL imaging for auxiliary validation of E2 concentrations.
  • Detected E2 in a range from 0.01 to 200 ng/mL
  • Achieved detection limits of 3.27 fg/mL in ECL mode and 6.76 fg/mL in EC mode
  • Demonstrated enhanced ECL performance through covalent bridging of AIEgen.

Cite This Study

Geng et al. (2026) studied this question.

synapsesocial.com/papers/69ba43f74e9516ffd37a5c2bhttps://doi.org/10.1021/acs.analchem.5c07619
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