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September 5, 2025Journal of Translational MedicineOpen Access

DDX27 in cancer: molecular mechanisms, clinical implications, and therapeutic potential

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Authors

LYLe YangSMSimon Wing-Fai MokHLHua Li

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Overview

This review highlights DDX27’s involvement in tumorigenesis and its potential as a cancer biomarker, suggesting innovative therapeutic avenues.

Key Points

  • DDX27 is significantly linked with cancer progression, with its expression correlating with negative clinical outcomes.
  • Molecular mechanisms like NF-κB activation and ERK1/2 phosphorylation play crucial roles in DDX27-related pathways.
  • Targeted therapies, such as RNA interference and miRNA-based approaches, show promise in modulating DDX27’s effects in cancer.
  • Significant limitations exist in current DDX27 research, underscoring the need for further investigation into its roles.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/68bb3edf2b87ece8dc956d93https://doi.org/10.1186/s12967-025-07004-1
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