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September 5, 2025Molecular Pharmaceutics

Harnessing Membrane-Targeting Photosensitizers to Evoke Ferroptosis and Pyroptosis Dual-Modal Cell Death for Antitumor Therapy

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Authors

YYYing YinCXCheng XiangDFDuoyang Fan

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Overview

Development of multifunctional photosensitizers induces ferroptosis and pyroptosis in tumors, suggesting enhanced treatment efficacy.

Key Points

  • TDTP induces synergistic ferroptotic-pyroptotic cell death, enhancing cancer treatment outcomes.
  • At a concentration of 26.07 nM, TDTP significantly ablates tumors in in vivo studies, outperforming traditional approaches.
  • This study uses a π-bridge engineering strategy to develop photosensitizers that target the plasma membrane and elevate therapeutic effects.
  • The findings highlight the potential of membrane-specific photosensitizers as theranostic agents for effective cancer treatment.

Cite This Study

Yin et al. (2025) studied this question.

synapsesocial.com/papers/68bb3ef02b87ece8dc957441https://doi.org/10.1021/acs.molpharmaceut.5c01042
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