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September 20, 2025Angewandte Chemie

Concurrent Ferroptosis and Pyroptosis Induced by a Dual‐Organelle‐Targeted Type I/II AIE Photosensitizer for Bladder Cancer Immunotherapy

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Authors

YCYifan ChengKZKun ZhouYCYuhang Chen

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Overview

Experimental analysis reveals enhanced antitumor effects through concurrent ferroptosis and pyroptosis in bladder cancer, suggesting novel immunotherapeutic strategies.

Key Points

  • Concurrent cell death mechanisms, including ferroptosis and pyroptosis, were achieved using a novel photosensitizer.
  • The photosensitizer DFTBPPY generated reactive oxygen species upon laser irradiation, leading to lipid peroxidation.
  • This dual-organelle-targeted approach enhances the therapeutic potential in bladder cancer, indicating a promising new strategy.
  • These findings highlight the role of lipid imbalance and oxidative stress in driving multiple cell death pathways.

Cite This Study

Cheng et al. (2025) studied this question.

synapsesocial.com/papers/68d46aae31b076d99fa67847https://doi.org/10.1002/ange.202509783
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Concurrent Ferroptosis and Pyroptosis Induced by a Dual‐Organelle‐Targeted Type I/II AIE Photosensitizer for Bladder Cancer Immunotherapy2025 · 17 citations
  2. 2Sequential induction of ferroptosis and pyroptosis in cancer cells by lipid droplet-targeting AIE theranostics2024 · 3 citations
  3. 3Harnessing Membrane-Targeting Photosensitizers to Evoke Ferroptosis and Pyroptosis Dual-Modal Cell Death for Antitumor Therapy2025 · 4 citations
  4. 4Iridium(III) Photosensitizers Induce Simultaneous Pyroptosis and Ferroptosis for Multi‐Network Synergistic Tumor Immunotherapy2024 · 19 citations
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