What type of study is this?

This is a Animal Study study (also classified as: Observational).

Myeloid-mesenchymal crosstalk drives ARG1-dependent profibrotic metabolism via ornithine in lung fibrosis

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Observational analysis reveals that ornithine drives collagen synthesis in lung fibrosis, indicating critical myeloid involvement.

Ornithine from myeloid cells fuels collagen synthesis in lung fibroblasts, worsening lung fibrosis.
Small-molecule inhibition of ARG1 reduced collagen expression and ornithine levels in lung slices.
Myeloid-specific Arg1 KO mice confirmed the role of ARG1 in modulating lung fibrosis severity.
Immune-mesenchymal interactions driven by purinergic signaling enhance fibrosis via IL-6 and ARG1 expression.

Yadav et al. (2025) studied this question.

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