P10 | Hypoalbuminemia predicts 6-month all-cause mortality in patients with acute decompensated heart failure

Introduction and Background: Hypoalbuminemia is common among elderly patients and it is associated with poor survival in patients hospitalized with acute decompensated heart failure (ADHF). We assessed the impact of hypoalbuminemia among older patients with ADHF admitted to an Internal Medicine division.Materials and Methods: This interim analysis includes 271 out of 498 patients as part of a retrospective cohort study of patients admitted for ADHF during 2022 to the Internal Medicine Division of Ospedale di Circolo and Fondazione Macchi, ASST Sette Laghi, Varese, Italy. Patients were included according to the discharge ICD-9-CM codes of ADHF. The primary endpoint is the prognostic role of hypoalbuminemia (<3.5 g/dL) toward 6-month all-cause mortality.Results: Out of 271 patients, 77.5% of patients had hypoalbuminemia. These ones were older, had more comorbidities (CCI) and frailty (CFS), had higher inflammation (NLR) and NT-proBNP. Across the 6-month follow-up, 30.6% of them died and the survival was much lower in patients with hypoalbuminemia than those with normoalbuminemia (35.7% vs. 13.1, log-rank χ² 11.49, p<0.001; unadjusted HR 3.28, 95% CI 1.58-6.80, p=0.001). Adjusting for potential confounders significant at the univariate analysis (age, obesity, CCI, CFS, NLR, NT-proBNP), hypoalbuminemia independently predicted 6-month all-cause mortality (adjusted HR 2.38, 95% CI 1.01-5.58, p=0.046).Conclusions: Hypoalbuminemia is very frequent among elderly patients admitted to an Internal Medicine division for ADHF and it is independently associated with 6-month all-cause mortality.