Key result
Hypoalbuminaemia (<35 g/L) was associated with a significantly increased risk of death in adult patients with congenital heart disease (HR 3.37; 95% CI 2.67-4.25; p<0.0001).
Why the study?
Does hypoalbuminaemia predict mortality in adult patients with congenital heart disease?
Population
2886 adult patients with congenital heart disease (ACHD), mean age 33.3 years, 50.1% men.
Comparison
Hypoalbuminaemia (<35 g/L) as an exposure vs Normal albumin levels
Design
Cohort
Follow-up
median 5.7 years (3.3-9.6)
Authors
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May enhance risk stratification in adult congenital heart disease; hypothesis-generating pending prospective validation.
Cohort (n=2,886)
No
Does hypoalbuminaemia predict mortality in adult patients with congenital heart disease?
Hazard Ratio: 3.37 (95% CI 2.67–4.25)
p-value: p=<0.0001
Hypoalbuminaemia is common in adult patients with congenital heart disease and is associated with a threefold increased risk of death, suggesting its utility in risk-stratification.
Kempny et al. (2015) conducted a cohort in Adult congenital heart disease (n=2,886). Hypoalbuminaemia vs. Normal albumin levels was evaluated on Mortality (HR 3.37, 95% CI 2.67-4.25, p=<0.0001). Hypoalbuminaemia (<35 g/L) was associated with a significantly increased risk of death in adult patients with congenital heart disease (HR 3.37; 95% CI 2.67-4.25; p<0.0001).
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