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September 5, 2025Italian Journal of MedicineOpen Access

P41 | Efficacy and safety of Roxadustat in patients with anemia of dialysis-dependent chronic kidney disease with or without inflammation: pooled analysis of four phase 3 studies

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Overview

Pooled analysis demonstrates roxadustat corrects hemoglobin in dialysis-dependent CKD patients, suggesting its effectiveness independent of inflammation levels.

Key Points

  • Roxadustat increased hemoglobin levels more than ESA in dialysis-dependent CKD patients, regardless of inflammation.
  • Change in hemoglobin from baseline after 28-52 weeks showed significant improvement with roxadustat treatment.
  • Four phase 3 trials (HIMALAYAS, ROCKIES, PYRENEES, SIERRAS) provided the data for this pooled analysis.
  • The safety profile of roxadustat was similar to that of ESA, with no increase in adverse events linked to hsCRP levels.

Cite This Study

A 2025 study studied this question.

synapsesocial.com/papers/68bb3efd2b87ece8dc957c0dhttps://doi.org/10.4081/itjm.2025.2233
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1P42 | Efficacy and safety of roxadustat in patients with non-dialysis-dependent chronic kidney disease with or without inflammation: pooled analysis of four phase 3 studies2025
  2. 2A retrospective study on the efficacy of Roxadustat in peritoneal dialysis patients with erythropoietin hyporesponsiveness2024 · 1 citations
  3. 3#1194 Roxadustat in ESA converted patients with anemia of chronic kidney disease on dialysis: a secondary analysis of ROXSTAR Registry2024
  4. 4Roxadustat for Erythropoiesis-Stimulating Agent Hyporesponsive Anemia in Hemodialysis: Multicenter Retrospective Analysis2026 · 1 citations
  5. 5Roxadustat in Kidney Transplant Recipients with ESA-Hyporesponsive Anemia: A Prospective Single-Center Cohort Study2026