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September 5, 2025Italian Journal of MedicineOpen Access

P42 | Efficacy and safety of roxadustat in patients with non-dialysis-dependent chronic kidney disease with or without inflammation: pooled analysis of four phase 3 studies

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Overview

Pooled analysis shows roxadustat improves hemoglobin levels in chronic kidney disease patients, suggesting safety regardless of inflammation.

Key Points

  • Roxadustat increased hemoglobin levels more than placebo, and comparable to ESA, in patients with chronic kidney disease.
  • The mean hemoglobin change from baseline was greater with roxadustat, indicating effective treatment for anemia.
  • Pooled analysis from four phase 3 studies evaluated efficacy and safety of roxadustat across various inflammation levels.
  • Supports the use of roxadustat for non-dialysis-dependent chronic kidney disease patients without needing higher doses.

Cite This Study

A 2025 study studied this question.

synapsesocial.com/papers/68bb3efd2b87ece8dc957c3dhttps://doi.org/10.4081/itjm.2025.2234
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1P41 | Efficacy and safety of Roxadustat in patients with anemia of dialysis-dependent chronic kidney disease with or without inflammation: pooled analysis of four phase 3 studies2025
  2. 2#1194 Roxadustat in ESA converted patients with anemia of chronic kidney disease on dialysis: a secondary analysis of ROXSTAR Registry2024
  3. 3A retrospective study on the efficacy of Roxadustat in peritoneal dialysis patients with erythropoietin hyporesponsiveness2024 · 1 citations
  4. 4Roxadustat for Erythropoiesis-Stimulating Agent Hyporesponsive Anemia in Hemodialysis: Multicenter Retrospective Analysis2026 · 1 citations
  5. 5Hb target achievement and associated predictors of roxadustat therapy across baseline anemia severities in maintenance hemodialysis: A single-center real-world retrospective cohort study2026