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Antinociceptive and motor-blocking effects of epidurally administered diphenhydramine at different concentrations in conscious rabbits: a randomized–controlled trial

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Randomized trial found 10% diphenhydramine offers prolonged analgesia with minimal motor blockade.

Epidural administration of 10% diphenhydramine resulted in 201 minutes of analgesia.
Motor blockade lasted an average of 157.2 minutes with 10% diphenhydramine compared to lidocaine.
Optimal dose for diphenhydramine was determined to be 12 mg kg-1 with effective sensory-selective block.
Diphenhydramine showed superior potency compared to lidocaine, offering safer analgesia in rabbits.

Ziaei-Darounkolaei et al. (2025) studied this question.

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