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A Chronic Model for Experimental Investigation of Epidural Anesthesia in the Rabbit

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Experimental investigation finds variable motor block durations in rabbits using lidocaine and bupivacaine.

Complete motor block duration varied with increasing doses of lidocaine, lasting an average of 27 to 51 minutes.
Linear relationships were identified between drug concentrations and motor block durations for both lidocaine and bupivacaine, with significant statistical values.
Epidural catheters remained implanted for two months without complications, supporting the model's reliability for further research.
Bupivacaine caused incomplete motor deficits in a few rabbits, while others achieved complete motor block, indicating varying efficacy.

Malinovsky et al. (1997) studied this question.

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