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September 5, 2025Open Access

Restraint of TGFβ family signaling by SMAD7 is necessary for hematopoietic stem cell maturation in the embryo.

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Authors

LBLaura BennettWYWenbao YuCCChia-Hui Chen

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Overview

Experimental analysis reveals SMAD7’s role in TGFβ and BMP signaling for pre-HSC maturation, indicating critical pathways in embryonic development.

Key Points

  • Deletion of Smad7 impairs the maturation of hematopoietic stem cells from pre-HSCs in embryonic development.
  • Data shows that both TGFβ and BMP signaling pathways must be down-regulated for effective pre-HSC to HSC maturation.
  • The formation of pre-HSCs from hemogenic endothelial cells occurs when Smad7 is deleted, emphasizing its regulatory role.
  • Understanding the signaling balance may lead to advancements in hematopoietic stem cell therapies.

Cite This Study

Bennett et al. (2025) studied this question.

synapsesocial.com/papers/68bb42142b87ece8dc9584f3https://doi.org/10.1101/2025.08.23.671940
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Restraint of TGF-β signaling by SMAD7 is necessary for the maturation of hematopoietic stem cells in the mouse embryo2025
  2. 2Transition of signal requirement in hematopoietic stem cell development from hemogenic endothelial cells2024 · 4 citations
  3. 3A subset of megakaryocytes regulates development of hematopoietic stem cell precursors2024 · 6 citations
  4. 4Developmental regulation of endothelial-to-hematopoietic transition from induced pluripotent stem cells2025
  5. 5TGF-β1-triggered maladaptive bone marrow endothelium impedes hematopoietic recovery2025 · 5 citations