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December 8, 2025Blood

Restraint of TGF-β signaling by SMAD7 is necessary for the maturation of hematopoietic stem cells in the mouse embryo

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Authors

JTJoanna ToberKTKai Tan

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Overview

Knockout of smad7 reduces functional hematopoietic stem cells in embryos, indicating its role in maturation and signaling regulation.

Key Points

  • The research investigates the role of smad7 in the maturation of hematopoietic stem cells in mouse embryos.
  • Analyzed effects of smad7 knockout on the number of HSCs and pre-HSCs in mouse embryos.
  • Performed limiting dilution transplants of AGM and fetal liver cells to assess HSC functionality.
  • Conducted scRNA-seq profiling of endothelial and IAHC cells from E11.5 embryos.
  • Complete loss of functional adult-repopulating HSCs observed in AGM of smad7 KO embryos.
  • An 85% reduction in functional pre-HSCs in smad7 KO IAHC cells compared to wild type.
  • Loss of smad7 increased the proportion of pre-HSCs but impaired their maturation to HSCs.

Cite This Study

Tober et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e237https://doi.org/10.1182/blood-2025-4929
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Restraint of TGFβ family signaling by SMAD7 is necessary for hematopoietic stem cell maturation in the embryo2025
  2. 2Transition of signal requirement in hematopoietic stem cell development from hemogenic endothelial cells2024 · 8 citations
  3. 3Spatial transcriptomics identified dynamic and spatial-resolved niche cell and signal architecture for hematopoietic stem cell specification2025
  4. 4A subset of megakaryocytes regulates development of hematopoietic stem cell precursors2024 · 10 citations
  5. 5Developmental regulation of endothelial-to-hematopoietic transition from induced pluripotent stem cells2025 · 3 citations