Cobalt-catalyzed regio-and stereoselective synthesis of atropisomers with vicinal C-C and C-N diaxes

Suman Ghosh; Partha Saha; Shib Nath Saha; Sanoop P. Chandrasekharan; Mainak Koner; Mahiuddin Baidya

doi:10.1039/d5cc04297f

January 1, 2025Chemical Communications

Cobalt-catalyzed regio-and stereoselective synthesis of atropisomers with vicinal C-C and C-N diaxes

View Full Paper

Ask AI

Bookmark

Share

Key Points

This method demonstrates regio-, diastereo-, and enantioselective synthesis of atropisomers.
A cobalt-catalyzed process features the creation of vicinal C-C and C-N diaxes for better selectivity.
The innovative approach takes advantage of C-H activation for effective annulation reactions.
Utilizing aromatic and alkenyl amides, this strategy opens pathways for developing complex heterocycles.

Implication

Cobalt-catalyzed C-H activation generates atropisomers in aromatic amides, suggesting unique pathways for heterocycles.

Abstract

A regio-, diastereo-, and enantioselective cobalt-catalyzed C-H activation/annulation of aromatic and alkenyl amides has been developed to access heterocycles featuring vicinal C-C and C-N diaxes. This strategy uniquely harnesses previously...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Ghosh et al. (2025) studied this question.

synapsesocial.com/papers/68bb42142b87ece8dc9585b6 https://doi.org/10.1039/d5cc04297f

View Full Paper

Ask AI

Bookmark

Share

Cobalt-catalyzed regio-and stereoselective synthesis of atropisomers with vicinal C-C and C-N diaxes

Key Points

Implication

Abstract

Discussion

Cite This Study

Cobalt-catalyzed regio-and stereoselective synthesis of atropisomers with vicinal C-C and C-N diaxes

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading