Atroposelective synthesis of isoquinolinone bearing two distinct C−N axes via cobalt-catalyzed enantioselective C−H activation/annulation

Wenkai Li; Liling Fu; Yongqiang Xu; Yuhan Zhou; Jingping Qu; Baomin Wang

doi:10.1039/d5cc05883j

January 1, 2025Chemical Communications

Atroposelective synthesis of isoquinolinone bearing two distinct C−N axes via cobalt-catalyzed enantioselective C−H activation/annulation

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Key Points

The enantioselective C−H activation leads to diverse isoquinolinones with dual C−N axes.
Using cobalt and Salox, this method shows efficient scaffold formation under mild conditions.
Concurrent construction of stereogenic axes opens new avenues in asymmetric synthesis exploration.
This method highlights the potential for creating complex structures rapidly with minimal steps.

Implication

Cobalt-catalyzed process achieves enantioselective C−H activation to create diverse scaffolds with distinct C−N axes, indicating potential in asymmetric synthesis.

Abstract

We report a Co/Salox-catalyzed atroposelective C–H activa-tion/annulation process that concurrently constructs dual C–N stereogenic axes under mild conditions. By incorporating acyclic axial chirality into 1,3-biaxial scaffolds, we achieve diverse multi-axial...

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/692b94261d383f2b2a3783e1 https://doi.org/10.1039/d5cc05883j

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Atroposelective synthesis of isoquinolinone bearing two distinct C−N axes via cobalt-catalyzed enantioselective C−H activation/annulation

Key Points

Implication

Abstract

Discussion

Cite This Study

Atroposelective synthesis of isoquinolinone bearing two distinct C−N axes via cobalt-catalyzed enantioselective C−H activation/annulation

Key Points

Implication

Abstract

Discussion

Cite This Study

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