Co/Salox Catalyzed Enantioselective C-H Annulation for One Step Elusive Generation of C-N Axial and C Central Chirality

Synthesis of multiple chiral centers with complete selectivity in a single step synthesis remains challenging. A novel strategy for the Co-catalyzed enantioselective annulation of N-(quinolin-8-yl) benzamide with the strained bicyclic alkenes has been demonstrated. This catalytic protocol enables double enantio induction to control C-N axis of low rotational barrier and carbon central chirality in one-step synthesis. The developed reaction can be performed with or without (electrooxidation, and photo-redox conditions) metal oxidant.