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September 5, 2025Veterinary and Comparative OncologyOpen Access

Immunophenotyping and Mutation Analysis of Canine Intestinal T‐Cell Lymphoma: A Comparative Pathological Study of Human Enteropathy‐Associated T‐Cell Lymphoma

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Authors

KKKazuhiro KojimaBunkyo UniversityJCJames ChambersBunkyo UniversityKNKo NakashimaJapan Small Animal Medical Center

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Overview

This analysis reveals gene mutations and immunophenotypic features in canine intestinal T-cell lymphoma, indicating similarities to human-associated conditions.

Key Points

  • Canine intestinal T-cell lymphoma shows significant immunophenotypic features similar to human EATL, highlighting cross-species relevance.
  • Gene mutation analysis found loss-of-function mutations in NF-κB pathway inhibitors in 31 out of 54 cases of canine ILTCL.
  • The study involved detailed immunophenotyping and RNA expression analysis of 54 canine ILTCL cases, comparing them to human EATL.
  • Findings suggest canine ILTCL may serve as a valuable model for studying the pathogenesis of human enteropathy-associated T-cell lymphoma.

Cite This Study

Kojima et al. (2025) studied this question.

synapsesocial.com/papers/68bb421a2b87ece8dc95873chttps://doi.org/10.1111/vco.70009
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comprehensive phenotypic and clonality analysis of intraepithelial lymphocytes of intestinal T-cell lymphoma and chronic enteropathy in dogs2026
  2. 2Clinical, Histopathological and Molecular Characterisation of Canine Epitheliotropic Cutaneous T‐Cell Lymphoma With Cytotoxic Interface Dermatitis: A Retrospective Case Series2025
  3. 3Abstract A022: A naturally occurring feline model for human indolent intestinal T-cell neoplasia2026
  4. 4Abstract A020: Characterizing the disease pathogenesis and translational potential of naturally occurring canine small cell B cell lymphoma2026
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