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September 5, 2025Frontiers in Bioengineering and BiotechnologyOpen Access

Drug delivery system based on an antibacterial layer-by-layer coating on urinary catheters: an experimental and simulation approach

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Authors

RPRuth PulidoNNNelson NaveasFFFrancisco Javier Fernández-Alonso

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Overview

Experimental and simulation approach demonstrates a drug delivery system's effectiveness against CAUTIs.

Key Points

  • The LbL-coated urinary catheters released more than twice the amount of ciprofloxacin compared to uncoated catheters.
  • Antibacterial efficacy of LbL coating showed significantly higher activity against S. aureus than E. coli.
  • Drug release modeling using Fick’s second law demonstrated a diffusivity of 1.744 × 10−5 cm²/h.
  • This dual strategy could effectively reduce catheter-associated urinary tract infections (CAUTIs) in clinical settings.

Cite This Study

Pulido et al. (2025) studied this question.

synapsesocial.com/papers/68bb42212b87ece8dc9589e8https://doi.org/10.3389/fbioe.2025.1614509
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nano-enabled enzyme-assisted layer-by-layer coating prevents biofilm formation on urinary catheters.2026 · 1 citations
  2. 2Electrostatically Assembled HA–DN/AMSN–TCS Coatings for Antibacterial Urinary Catheters2026
  3. 3Ag nanoparticles embedded in microcapsules within a hydrogel coating on urinary catheters: lubricity, antibacterial, and antibiofouling properties2026 · 2 citations
  4. 4Mussel-Inspired Sonochemical Nanocomposite Coating on Catheters for Prevention of Urinary Infections2024 · 15 citations
  5. 5Dual‐Layer Nanoengineered Urinary Catheters for Enhanced Antimicrobial Efficacy and Reduced Cytotoxicity2024 · 21 citations