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September 5, 2025International Journal of Molecular SciencesOpen Access

Dysregulation of MicroRNAs in Hepatocellular Carcinoma: Targeting Oncogenic Signaling Pathways for Innovative Therapies

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Authors

YZYusra ZarlashatGovernment College University, FaisalabadJHJudit HalászSemmelweis UniversityEDEdit DósaSemmelweis University

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Implication

Review reveals microRNAs regulate oncogenic signaling pathways in hepatocellular carcinoma, suggesting novel therapies.

Key Points

  • Dysregulation of microRNAs can promote tumor growth and treatment resistance in hepatocellular carcinoma.
  • Preclinical studies show that targeting specific microRNAs can effectively reduce HCC progression and improve survival rates.
  • Strategies like restoring tumor-suppressive microRNAs or inhibiting oncogenic ones can enhance HCC therapy outcomes.
  • Combination therapies utilizing nanoparticles to deliver specific microRNAs show promise for treating HCC.

Cite This Study

Zarlashat et al. (2025) studied this question.

synapsesocial.com/papers/68bb42272b87ece8dc958f66https://doi.org/10.3390/ijms26178365
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Also Consider

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  1. 1Lipid Nanoparticles as a Platform for miRNA and siRNA Delivery in Hepatocellular Carcinoma2024 · 10 citations
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  5. 5MicroRNA-197 Promotes Metastasis of Hepatocellular Carcinoma by Activating Wnt/β-Catenin Signaling2018 · 47 citations