Prognostic Significance of Cancer Stem Cell Markers and Tumor Microenvironment Components for Assessing the Efficacy of Chemoradiotherapy in Patients with Locally Advanced rectal cancer
Research assesses cancer stem cell markers and tumor microenvironment in predicting chemoradiotherapy response in rectal cancer patients, highlighting prognostic implications.
Key Points
High expression of cancer stem cell markers predicts poor response to chemoradiotherapy in rectal cancer.
Among patients with poor treatment response, 78.4% had ALDH1 >20%, significantly higher than the 26.3% with better outcomes.
Tumor regression grade was evaluated in 75 patients, analyzing associations between marker expression and treatment response.
Integration of these biomarkers into treatment strategies may enhance personalized therapy for rectal cancer patients.