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July 1, 2026Journal of Clinical MedicineOpen Access

Association of Pretreatment Immune-Inflammatory Biomarkers with Pathological Tumor Regression Following Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer

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Authors

AEAhmet Sencer ErginBDBurçin Çakan DemirelŞBŞahin Bedir

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Overview

Retrospective study evaluates biomarkers in relation to tumor response in advanced rectal cancer, suggesting limited predictiveness.

Key Points

  • The aim is to assess how pretreatment immune-inflammatory biomarkers relate to tumor regression after neoadjuvant chemoradiotherapy in locally advanced rectal cancer.
  • Retrospective study of 88 patients with stage II–III rectal adenocarcinoma
  • Comparison of inflammatory biomarkers across tumor regression grades
  • Receiver operating characteristic and logistic regression analyses conducted for pathological complete response.
  • No significant differences in biomarkers across tumor regression groups
  • Monocyte count had the best discriminatory performance for pathological complete response (AUC = 0.663)
  • Biomarkers were not independently predictive of pathological complete response after adjustments for clinical factors.

Cite This Study

Ergin et al. (2026) studied this question.

synapsesocial.com/papers/6a44afdc5cd2549c8bc44bc5https://doi.org/10.3390/jcm15135039
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic Value of Dynamic Changes in Immune-Inflammatory and Tumor Biomarkers Following Chemoradiotherapy in Locally Advanced Rectal Cancer2025 · 6 citations
  2. 2Immune-inflammatory indices as predictors of pathologic complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a systematic review and meta-analysis of observational studies2026 · 2 citations
  3. 3New Parameters That May Predict Tumor Regression and Survival in Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer2025
  4. 4A Retrospective Study of a Postoperative Inflammation-Based Score for Predicting Disease-Free Survival in Locally Advanced Rectal Cancer After Neoadjuvant Chemoradiotherapy2026 · 1 citations
  5. 5Predictive value of flexible proctosigmoidoscopy and laboratory findings for complete clinical responses after neoadjuvant chemoradiotherapy in patients with locally advanced primary rectal cancer: a retrospective cohort study2024 · 1 citations