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September 5, 2025Annals of Clinical Microbiology and AntimicrobialsOpen Access

Efflux pumps positively contribute to rifampin resistance in rpoB mutant Mycobacterium tuberculosis

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Authors

FMFanrong MengQCQian ChenZWZeyou Wei

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Overview

Analysis reveals efflux pumps enhance rifampin resistance in Mycobacterium tuberculosis strains with rpoB mutations, suggesting potential therapeutic targets.

Key Points

  • Efflux pump overexpression contributes to increased rifampin resistance in Mycobacterium tuberculosis strains.
  • Treatment with verapamil reduced the MIC for rifampin in clinical isolates with rpoB mutations.
  • The study evaluated the expression of 13 efflux pump genes in 35 rifampicin-resistant Mycobacterium tuberculosis isolates.
  • Rifampin resistance levels varied based on specific rpoB codon mutations, influencing efflux pump activity.

Cite This Study

Meng et al. (2025) studied this question.

synapsesocial.com/papers/68bb46bd6d6d5674bccfeb0ehttps://doi.org/10.1186/s12941-025-00816-5
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Also Consider

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  1. 1Mutations inside rifampicin-resistance determining region of rpoB gene associated with rifampicin-resistance in Mycobacterium tuberculosis2018 · 234 citations
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