Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025

Putative MFS transporter Rv1250 of Mycobacterium tuberculosis is involved in multidrug efflux activity

View Full Paper
Ask AI
Bookmark
Share

Authors

DCDebasmita ChatterjeeASAjit Ramesh SawantAPAditya Prasad Panda

Discussion

Loading...

Member takes

Overview

Study demonstrates Rv1250's role as an efflux pump in Mycobacterium tuberculosis, suggesting its impact on drug resistance.

Key Points

  • Rv1250 influences the extrusion of multiple drug classes, enhancing drug resistance mechanisms.
  • The study reveals a decrease in susceptibility to antibiotics, including fluoroquinolones and beta-lactams, due to rv1250 expression.
  • Biofilm formation is significantly enhanced in host cells expressing rv1250, indicating a survival strategy under antibiotic stress.
  • Efflux activity of Rv1250 leads to lower levels of antibiotic accumulation in host cells, suggesting intrinsic drug tolerance.

Cite This Study

Chatterjee et al. (2025) studied this question.

synapsesocial.com/papers/68c1c32e54b1d3bfb60f1660https://doi.org/10.1101/2025.08.06.668847
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1P-type ATPase zinc transporter Rv3270 of Mycobacterium tuberculosis enhances multi-drug efflux activity2024 · 10 citations
  2. 2The efflux pumps Rv1877 and Rv0191 play differential roles in the protection of Mycobacterium tuberculosis against chemical stress2024 · 4 citations
  3. 3Protonation Based Molecular Mechanism Behind Rv0191 Efflux Transporter Conferring Pyrazinamide Resistance in <i>Mycobacterium tuberculosis</i>2026
  4. 4Efflux pumps positively contribute to rifampin resistance in rpoB mutant Mycobacterium tuberculosis2025 · 4 citations
  5. 5Novel mutation in efflux pump Rv1258c (Tap) gene in drug resistant clinical isolates of Mycobacterium tuberculosis in Iran2024 · 1 citations