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September 5, 2025Folia Pharmacologica Japonica

Insulin signaling and neuropathological changes in Alzheimer’s disease

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Authors

TWTomoko Wakabayashi

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Overview

This review examines insulin signaling and neuropathology in Alzheimer's disease, highlighting type 2 diabetes as a risk factor.

Key Points

  • Reduced insulin signaling may inhibit amyloid-β pathology in Alzheimer’s disease, while worsening insulin resistance can accelerate its deposition.
  • Recent studies using amyloid PET imaging clarify the relationship between type 2 diabetes and amyloid-β accumulation in the brain.
  • Epidemiological and experimental evidence shows that type 2 diabetes and insulin resistance are significant risk factors for Alzheimer’s disease.
  • Diet-induced insulin resistance in animal studies promotes amyloid-β accumulation, underscoring the need for early interventions in Alzheimer's.

Cite This Study

Tomoko Wakabayashi (2025) studied this question.

synapsesocial.com/papers/68bb46c36d6d5674bccfef44https://doi.org/10.1254/fpj.25019
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