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April 15, 2026Geriatrics and gerontology international/Geriatrics & gerontology internationalOpen Access

Peripheral Insulin Resistance and Alzheimer's Disease: Possible Mediators Including Extracellular Vesicles

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Authors

NINaotaka IzuoHKHiroshi KondohTSTakahiko Shimizu

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Overview

This review examines the link between peripheral insulin resistance and Alzheimer's disease, indicating potential mediators like extracellular vesicles.

Key Points

  • The aim is to explore the relationship between peripheral insulin resistance and Alzheimer’s disease, focusing on mediators involved in this process.
  • Review of epidemiological studies linking type 2 diabetes and Alzheimer's disease.
  • Analysis of animal studies addressing insulin resistance's effects on brain function.
  • Evaluation of evidence regarding extracellular vesicles in central-peripheral communication.
  • Insulin resistance is significantly related to earlier amyloid β accumulation.
  • Cognitive decline linked to insulin resistance occurs independently of Aβ deposition.
  • Extracellular vesicles may facilitate communication between peripheral insulin resistance and brain vulnerability.

Cite This Study

Izuo et al. (2026) studied this question.

synapsesocial.com/papers/69df2cf7e4eeef8a2a6b2023https://doi.org/10.1111/ggi.70483
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