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September 5, 2025Folia Pharmacologica Japonica

Application of neural organoids containing microglia to neurodegenerative disease research

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Authors

KHKoki HaradaKyoto Pharmaceutical UniversityKTKazuyuki TakataKyoto Pharmaceutical University

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Implication

Review explores how neural organoids improve understanding of pathogenic mechanisms in Alzheimer's disease, highlighting the role of microglia in therapy development.

Key Points

  • Neural organoids could bridge the translational gap seen in Alzheimer's disease therapy development, providing a human-relevant model.
  • Microglia play a crucial role in understanding Alzheimer's, with research trends focusing on these immune cells within neural organoids.
  • Pluripotent stem cells allow for generating neural organoids, which can mimic 3D brain structures and function good for drug testing.
  • Combining gene editing with patient-derived stem cells enhances the potential of neural organoids to advance therapeutic strategies.

Cite This Study

Harada et al. (2025) studied this question.

synapsesocial.com/papers/68bb46c36d6d5674bccfef4ahttps://doi.org/10.1254/fpj.25034
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