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June 11, 2026Current Neuropharmacology

Exploring the Cellular and Molecular Mechanisms Underlying Alzheimer's Disease Utilizing Cerebral Organoids Derived from Patient-specific Induced Pluripotent Stem Cells (iPSCs): A Review with Implications for Surgical Interventions

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Authors

HSHarpreet SinghBSBhuvnesh Kumar SinghAKAnil Kumar

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Overview

Review explores mechanisms of Alzheimer's disease using patient-specific stem cells, highlighting implications for therapies.

Key Points

  • The aim is to explore the cellular and molecular mechanisms of Alzheimer's disease using iPSC-derived cerebral organoids.
  • Review of literature on iPSC technology and its application in modeling Alzheimer's disease.
  • Discussion of advances in organoid technology including cortical organoids and their relevance to AD pathology.
  • Analysis of challenges such as reproducibility, maturation, and clinical translation.
  • Cerebral organoids effectively model amyloid and tau pathology, enabling better understanding of synaptic dysfunction.
  • Innovations like microglial integration and cellular aging enhance the validity of AD studies.
  • Ethical and regulatory considerations for stem cell research are pivotal for future clinical applications.

Cite This Study

Singh et al. (2026) studied this question.

synapsesocial.com/papers/6a2a523480c8f91e7f39e371https://doi.org/10.2174/011570159x428563260430050900
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Advances in <scp>hiPSC</scp> ‐Derived Brain Organoids as a Model to Study Neuroinflammation in Alzheimer's Disease2026
  2. 2Advances in the Application of Pluripotent Stem Cells in the Research and Treatment of Neurological Diseases2025 · 1 citations
  3. 3Application of neural organoids containing microglia to neurodegenerative disease research2025
  4. 4Stimulus-Based ApoE Alzheimer’s Disease Induction Model Using Microglia-Containing Brain Organoids for Drug Discovery2026 · 1 citations
  5. 5Generation of Alzheimer’s Disease Model Derived from Induced Pluripotent Stem Cells with APP Gene Mutation2024 · 1 citations