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September 5, 2025Gene & Protein in DiseaseOpen Access

Bioinformatics analysis of the GEO database for the identification of novel biomarkers and potential targeted drugs for pulmonary hypertension

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Authors

ZLZhendong LüZJZhi-Liang JiangWHWahab Hussain

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Overview

This analysis uncovers 311 differentially expressed genes and highlights immune infiltration in pulmonary hypertension, suggesting novel therapeutic interventions.

Key Points

  • A total of 311 differentially expressed genes were identified, including 182 upregulated and 129 downregulated, indicating significant molecular changes in pulmonary arterial hypertension.
  • Linear Models for Microarray Data analysis revealed important functional pathways related to inflammation and extracellular matrix organization linked to PAH.
  • Drug prediction highlighted retinol, arsenic trioxide, and active vitamin D as potential therapeutics, which may regulate identified hub genes effectively.
  • Macrophage-associated genes play crucial roles in vascular inflammation and remodeling, emphasizing their importance in the pathology of pulmonary arterial hypertension.

Cite This Study

Lü et al. (2025) studied this question.

synapsesocial.com/papers/68bb46c96d6d5674bccff33dhttps://doi.org/10.36922/gpd025080018
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bioinformatics-based identification and experimental validation of biomarkers in pulmonary arterial hypertension2026
  2. 2Bioinformatics Analysis and Experimental Validation to Identify Hub Genes in Pulmonary Arterial Hypertension2025
  3. 3Identification of hub genes based on integrated analysis of single-cell and microarray transcriptome in patients with pulmonary arterial hypertension2023 · 19 citations
  4. 4Identification and Validation of Potential Diagnostic Biomarkers for Pulmonary Arterial Hypertension Based on Gene Expression Profiling2025
  5. 5Integrative transcriptomic analysis identifies immune-associated candidate genes and altered immune cell infiltration in pulmonary arterial hypertension2026