What question did this study set out to answer?

This study aimed to identify immune-associated hub genes in pulmonary arterial hypertension and validate their relevance in an experimental model.

May 24, 2026PLoS ONEOpen Access

Integrative transcriptomic analysis identifies immune-associated candidate genes and altered immune cell infiltration in pulmonary arterial hypertension

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Authors

XYXitong Yang BZBin Zhou YYYing Yang

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Overview

Integrative analysis identifies immune-associated hub genes and altered immune infiltration in pulmonary arterial hypertension, suggesting new targets for research.

Key Points

This study aimed to identify immune-associated hub genes in pulmonary arterial hypertension and validate their relevance in an experimental model.
Analyzed three PAH lung transcriptomic datasets from the Gene Expression Omnibus (GEO).
Estimated immune cell infiltration using single-sample gene set enrichment analysis (ssGSEA).
Prioritized hub genes through weighted gene co-expression network analysis (WGCNA) and machine learning algorithms.
Identified 8 hub genes, with BCLAF1 showing the highest diagnostic performance.
Significant alterations in T helper cell subsets and correlations between hub genes and immune signatures were found.
In the PAH murine model, BCLAF1, CDC5L, SMARCA5, and ASH1L were upregulated, correlating with increased collagen deposition.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a1295e248a0ea166567238f https://doi.org/10.1371/journal.pone.0350015

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May 24, 2026PLoS ONEOpen Access

Integrative transcriptomic analysis identifies immune-associated candidate genes and altered immune cell infiltration in pulmonary arterial hypertension

View Full Paper

Ask AI

Bookmark

Authors

XYXitong Yang BZBin Zhou YYYing Yang

Discussion

Member takes

Overview

Integrative analysis identifies immune-associated hub genes and altered immune infiltration in pulmonary arterial hypertension, suggesting new targets for research.

Key Points

This study aimed to identify immune-associated hub genes in pulmonary arterial hypertension and validate their relevance in an experimental model.
Analyzed three PAH lung transcriptomic datasets from the Gene Expression Omnibus (GEO).
Estimated immune cell infiltration using single-sample gene set enrichment analysis (ssGSEA).
Prioritized hub genes through weighted gene co-expression network analysis (WGCNA) and machine learning algorithms.
Identified 8 hub genes, with BCLAF1 showing the highest diagnostic performance.
Significant alterations in T helper cell subsets and correlations between hub genes and immune signatures were found.
In the PAH murine model, BCLAF1, CDC5L, SMARCA5, and ASH1L were upregulated, correlating with increased collagen deposition.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a1295e248a0ea166567238f https://doi.org/10.1371/journal.pone.0350015

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