Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 20, 2022Frontiers in Molecular BiosciencesOpen Access

MAPK6 was identified as a crucial hub gene to discriminate idiopathic pulmonary arterial hypertension from normal controls with an AUC of 100%.

View Full Paper
Ask AI
Bookmark
Share

Population

Gene expression profiles from dataset GSE113439 and lung tissues of rats with pulmonary artery hypertension

Comparison

Integrated bioinformatics methods and qPCR… vs Normal group

Design

Preclinical

Key result

MAPK6 was identified as a crucial hub gene to discriminate idiopathic pulmonary arterial hypertension from normal controls with an AUC of 100%.

Authors

XYXiaomei YangCWCheng WangYLYicheng Lin

Discussion

Loading...

Member takes

Overview

Bioinformatics insights into IPAH immune pathways should not change practice; leaves open need for prospective validation.

Structured PICO

P
Population
Gene expression profiles from dataset GSE113439 (idiopathic pulmonary arterial hypertension vs normal) and lung tissues of rats with pulmonary artery hypertension
E
Exposure
Integrated bioinformatics methods (PPI network, GSEA, GO enrichment, LASSO regression, ImmuCellAI) and qPCR validation
C
Comparator
Normal group
O
Outcome
Identification of crucial hub genes and differential T cell infiltrationsurrogate

Main Result

Effect estimate: AUC 100%

MAPK6 is a crucial hub gene that discriminates idiopathic pulmonary arterial hypertension from normal tissue, highlighting the role of dysregulated T cell immune reactions in the disease.

Cite This Study

Yang et al. (2022) studied Idiopathic pulmonary arterial hypertension (IPAH). MAPK6 expression vs. Normal group was evaluated on Discrimination of IPAH from normal group (AUC 100%). MAPK6 was identified as a crucial hub gene to discriminate idiopathic pulmonary arterial hypertension from normal controls with an AUC of 100%.

synapsesocial.com/papers/6aae38b9668337169243bd77https://doi.org/10.3389/fmolb.2022.800888
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of immune-related hub genes and analysis of infiltrated immune cells of idiopathic pulmonary artery hypertension2023 · 4 citations
  2. 2Integrative transcriptomic analysis identifies immune-associated candidate genes and altered immune cell infiltration in pulmonary arterial hypertension2026
  3. 3Identification of key driver genes in idiopathic pulmonary arterial hypertension by single-cell RNA sequencing and experimental validation.2026
  4. 4Bioinformatics Analysis and Experimental Validation to Identify Hub Genes in Pulmonary Arterial Hypertension2025
  5. 5A new integrative analysis of histopathology and single cell RNA-seq reveals the CCL5 mediated T and NK cell interaction with vascular cells in idiopathic pulmonary arterial hypertension2024 · 14 citations