This research demonstrates significant antioxidant and cytotoxic activities of Tinospora cordifolia, suggesting its potential for EGFR-targeted therapies.
Key Points
Tinospora cordifolia's methanolic extract shows strong antioxidant and cytotoxic effects against cancer cells.
The extract's IC₅₀ values were 235 µg/mL in antioxidant assays and 14.3 µg/mL for DLA cells, highlighting its potency.
Molecular docking studies revealed Tinocordiside's favorable binding to EGFR with a Glide score close to the known drug Erlotinib.
Density functional theory identified Tinocordiside as a promising candidate for EGFR inhibition with the lowest chemical potential.