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September 5, 2025Phytotherapy Research

A Systematic and Ethnobotanical Review of Ashwagandha's (Withania Somnifera) Teratogenic and Abortifacient Potentials

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Authors

MTMark J. TallonIKIgor KoturbashJBJason L. Blum

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Overview

Systematic review finds inconclusive evidence on teratogenic and abortifacient potential of ashwagandha, indicating the need for high-quality research.

Key Points

  • Evidence supporting significant teratogenic or abortifacient activity remains inconclusive despite historical claims.
  • Animal studies demonstrate high tolerability with no significant reproductive toxicity at human-relevant doses.
  • Observational analysis following PRISMA guidelines evaluated ashwagandha's reproductive toxicity and traditional usage.
  • This review emphasizes the necessity for standardized research into fertility and safety before regulatory actions.

Cite This Study

Tallon et al. (2025) studied this question.

synapsesocial.com/papers/68bb49bc6d6d5674bccff3fehttps://doi.org/10.1002/ptr.70079
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review2025 · 7 citations
  2. 2Biosafety Assessment of Shagandha, Standardized Extract From the Roots of <i>Withania somnifera</i>2026
  3. 3Comprehensive safety evaluation of Withania somnifera (Ashwagandha): an AI-driven meta-analysis and quantitative structure–activity relationship based toxicity assessment2025
  4. 4Ashwagandha under fire: A critical scientific analysis of regulatory decisions2024 · 5 citations
  5. 5The dark side of herbal medicine - risks of Ashwagandha (Withania Somnifera) consumption2024