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September 5, 2025Frontiers in TransplantationOpen Access

Plasma total and donor-derived cell-free DNA predict survival in kidney transplant recipients

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Authors

AGAlison GraverThe University of Melbourne DPDavid A. PowerAustin Hospital JWJohn WhitlamThe University of Melbourne

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Implication

Observational analysis identified high total cfDNA as a predictor of death in kidney transplant recipients, indicating ddcfDNA's potential role in patient outcomes.

Key Points

High total cfDNA levels predicted death in kidney transplant recipients, revealing important prognostic value for patient monitoring.
During a median follow-up of 6.3 years, 7 patients died, and high total cfDNA levels were associated with higher risk of death.
The study analyzed total cfDNA and ddcfDNA levels in 49 adult kidney transplant recipients during allograft biopsy to assess survival outcomes.
Incorporating total cfDNA and fractional ddcfDNA as biomarkers could support personalized care for kidney transplant recipients.

Cite This Study

Graver et al. (2025) studied this question.

synapsesocial.com/papers/68bb49c46d6d5674bccff762 https://doi.org/10.3389/frtra.2025.1624291

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Implication

Observational analysis identified high total cfDNA as a predictor of death in kidney transplant recipients, indicating ddcfDNA's potential role in patient outcomes.

Plasma total and donor-derived cell-free DNA predict survival in kidney transplant recipients

Discussion

Member takes

Implication

Key Points

Cite This Study

Plasma total and donor-derived cell-free DNA predict survival in kidney transplant recipients

Discussion

Member takes

Implication

Key Points

Cite This Study

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