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September 5, 2025Chemical Communications

Reductive ortho-Cyanomethylation of Aryl Iodanes with MeCN via One-pot Iodonium-Claisen Rearrangement

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Authors

BPBo PengLZLei ZhangMZMengjiao Zhu

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Overview

One-pot iodonium-Claisen rearrangement achieves ortho-cyanomethylation in aryl iodanes, suggesting new pathways for synthesizing arylacetonitriles.

Key Points

  • The iodonium-Claisen rearrangement provides an efficient method for ortho-cyanomethylation.
  • Using acetonitrile, the reaction creates arylacetonitriles from aryl iodanes.
  • This one-pot reaction simplifies preparation by generating intermediates in situ.
  • The approach may open new avenues for synthesizing valuable arylacetonitriles.

Cite This Study

Peng et al. (2025) studied this question.

synapsesocial.com/papers/68bb49cc6d6d5674bccffaa2https://doi.org/10.1039/d5cc04363h
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