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The study demonstrates efficient alkenylation and heteroarylation in N-phenoxyacetamides using iodonium ylides, highlighting functional group tolerance.
Herein, we describe a rhodium-catalyzed monoheteroarylation and alkenylation of N-phenoxyacetamides using iodonium ylides derived from cyclo-1,3-diones. This approach efficiently delivers novel heteroarylated and alkenylated products under mild reaction conditions. The protocol showcases good functional group tolerance and a wide substrate scope. Furthermore, this allows for smooth scale-up synthesis. Additional transformation experiments were conducted to highlight the potential synthetic utility of this methodology.
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Ding et al. (2025) studied this question.
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