Rh(III)-catalyzed C-H [4 + 2] annulation of oximes with (hetero)cyclic iodonium ylides to access pyrano[4,3-b]pyridin-5one derivatives

Q: What type of study is this?

This is a Experimental Study study.

H. -L. Cui; Shijin Zhou; Borong Su; Bin Yang; Shaoyu Mai; Huaming Tao

doi:10.1039/d5qo01370d

October 31, 2025Organic Chemistry Frontiers

Rh(III)-catalyzed C-H [4 + 2] annulation of oximes with (hetero)cyclic iodonium ylides to access pyrano[4,3-b]pyridin-5one derivatives

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Key Points

C-H annulation of oximes enables synthesis of valuable derivatives.
The external oxidant-free approach shows broad applicability in the field.
Rh(III)-catalyzed reactions provide an efficient pathway for compound formation.
The method's significance lies in generating medicinal compounds under optimized conditions.

Implication

This method demonstrates a new synthesizing approach for pyrano[4,3-b]pyridin-5-one derivatives, highlighting the effectiveness of C-H annulation with reaction conditions.

Abstract

We herein report a Rh(III)-catalyzed C-H [4 + 2] annulation of oximes with iodonium ylides, enabling efficient access to medicinally valuable pyrano [4,3-b]pyridin-5-one derivatives. This external oxidant-free approach demonstrates broad...

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Cite This Study

Cui et al. (2025) studied this question.

synapsesocial.com/papers/69054ffa1a99e50463de6767 https://doi.org/10.1039/d5qo01370d

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Rh(III)-catalyzed C-H [4 + 2] annulation of oximes with (hetero)cyclic iodonium ylides to access pyrano[4,3-b]pyridin-5one derivatives

Key Points

Implication

Abstract

Discussion

Cite This Study

Rh(III)-catalyzed C-H [4 + 2] annulation of oximes with (hetero)cyclic iodonium ylides to access pyrano[4,3-b]pyridin-5one derivatives

Key Points

Implication

Abstract

Discussion

Cite This Study

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