Investigates regioselective phenoxyl-arylation of ynamides, suggesting efficient production of ketene N,O-acetals.
This work describes an efficient Pd-catalyzed regioselective phenoxyl-arylation of ynamides with aryl iodides and phenols, providing a wide variety of tetrasubstituted ketene N,O-acetals in up to 99% yield. The reaction likely involves a syn-oxypalladation of the ynamide.
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Wang et al. (2026) studied this question.
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