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Spreading pattern of phosphorylated tau-positive granular glial pathology in the cerebral white matter of patients with multiple system atrophy

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Observational analysis reveals unique spreading of phosphorylated tau in cerebral white matter of MSA, highlighting potential biomarkers.

A distinct spreading pattern of phosphorylated tau pathology was discovered in the cerebral white matter of MSA patients, impacting diagnosis.
Severity of phosphorylated tau pathology significantly correlated with disease duration and tracheostomy duration, reinforcing clinical relevance.
Examination of multiple brain regions in 14 confirmed MSA cases revealed ongoing pathology across various white matter areas, illuminating its distribution.
Findings indicate phosphorylated tau pathology as a common aspect of MSA, suggesting its potential as a biomarker for monitoring disease progression.

Homma et al. (2025) studied this question.

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