Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 5, 2025Organic Letters

Divergent Synthesis of gem-Difluoro-2-oxabicyclo2.1.1hexanes Enabled by 1,3-Oxygen Rearrangement

View Full Paper
Ask AI
Bookmark
Share

Authors

MWMengyu WuNanjing Tech UniversityJWJiali WangNanjing Tech UniversitySWShiguan WangNanjing Tech University

Discussion

Loading...

Member takes

Overview

Photocatalytic method demonstrates efficient synthesis of bioisosteres in gram-scale production, highlighting its pharmaceutical potential.

Key Points

  • This method enables efficient synthesis of gem-difluoro-2-oxabicyclo[2.1.1]hexanes using visible light.
  • Cross [2 + 2] cyclization of difluoroallyl vinyl ethers yields access to distinct isomers with high efficiency.
  • 1,3-oxygen rearrangement proves crucial for converting γ,γ-difluoroallyl vinyl ethers to their α,α-difluorinated forms.
  • Successful gram-scale synthesis maintains excellent yields, suggesting strong applicability in pharmaceutical development.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/68bb49d26d6d5674bcd000edhttps://doi.org/10.1021/acs.orglett.5c03367
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Photocatalyzed Formation of <i>gem</i>‐Difluoroalkenes Using Oxime Esters2024 · 3 citations
  2. 2Visible-Light-Mediated Divergent Difunctionalization of <i>gem</i>-Difluoroalkenes Using Aryldiazonium Tetrafluoroborates2025
  3. 3Photocatalytic Difluoromethylation Cyclization and Dioxygen Trapping: Access to <i>gem</i> -Difluoro-Quinolines2026 · 3 citations
  4. 4Photoredox Catalyzed Synthesis of <i>gem</i>-Difluoroalkenes and Monofluorinated Cyclooctenes via 1,5-HAT Process2024 · 11 citations
  5. 5<i>gem</i>-Difluoroalkylation of Cyclic Ethers Enabled by Cobalt-Catalyzed C(sp<sup>3</sup>)–H Oxidation under Mild Conditions2024 · 2 citations