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September 5, 2025Annals of MedicineOpen Access

Clinical and hematological characteristics of beta-plus thalassemia and uncommon beta-chain hemoglobin variants in Northern Thailand

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Authors

PRPunwadee RukwongRNRungrote NatesirinilkulLSLalita Sathitsamitphong

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Overview

Observational analysis reveals clinical characteristics of beta-thalassemia and hemoglobin variants in Northern Thailand, highlighting mutation impact.

Key Points

  • Beta-thalassemia results from mutations affecting production of β-globin, leading to hereditary anemia.
  • Mutations in the HBB gene account for 10-20% of beta-thalassemia cases in Thailand.
  • Clinical characteristics of beta-thalassemia have been poorly characterized, indicating a gap in knowledge.
  • This analysis examines the clinical and hematological features in a specific geographic population.

Cite This Study

Rukwong et al. (2025) studied this question.

synapsesocial.com/papers/68bb49db6d6d5674bcd0025ahttps://doi.org/10.1080/07853890.2025.2551815
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1B+-Thalassemia Trait: Hematologic and Hemoglobin Synthesis Studies1976 · 17 citations
  2. 2Common hemoglobin variants affecting the diagnosis of β-thalassemia: A large cohort data at a single center2026 · 1 citations
  3. 3Compound Heterozygous Hemoglobin Minneapolis-Laos and Codon 41/42 (-TTCT) in a Thai Female Adult: A Case Report and Literature Review2026
  4. 4Dominant Beta Thalassemia: A Very Rare Cause of Thalassemia in a Mediterranean Country2024 · 1 citations
  5. 5Molecular epidemiology and hematological profiles of hemoglobin variants in southern Thailand2024 · 2 citations