What question did this study set out to answer?

Compare hematologic parameters and globin chain synthesis rates between individuals carrying beta-plus-thalassemia and beta-zero-thalassemia traits.

January 1, 1976Hemoglobin

B+-Thalassemia Trait: Hematologic and Hemoglobin Synthesis Studies

View Full Paper

Ask AI

Bookmark

Authors

SPS. PootrakulMinistry of Public Health SASurang AssawamunkongSiriraj Hospital SNS Na-NakornSiriraj Hospital

Discussion

Member takes

Implication

Comparative study shows globin chain synthesis ratios distinguish beta-plus from beta-zero thalassemia trait in Thai individuals, highlighting its utility for carrier classification.

Key Points

Compare hematologic parameters and globin chain synthesis rates between individuals carrying beta-plus-thalassemia and beta-zero-thalassemia traits.
Evaluated hematologic indices including hemoglobin concentration, MCV, MCH, MCHC, Hb A2, and alkali denaturation hemoglobin in 30 individuals of Thai and Chinese extraction with beta+-thalassemia trait.
Measured reticulocyte globin chain synthesis using 3H-leucine incorporation over 3 hours to determine alpha/beta ratios across beta+-thalassemia traits (n=9), beta0-thalassemia traits (n=7), and healthy controls (n=11).
Hematologic means for beta+-thalassemia traits were hemoglobin 11.7 g%, MCV 67.8 µm³, MCH 21.5 pg, MCHC 32.1%, Hb A2 4.94%, and alkali denaturation hemoglobin 1.20%, which did not differ statistically from beta0-thalassemia traits.
The mean alpha/beta globin synthesis ratio in beta+-thalassemia traits was 2.03 ± 0.10 SD, which differed significantly from the 2.28 ± 0.07 SD observed in beta0-thalassemia traits (control mean: 1.07 ± 0.03 SD).

Cite This Study

Pootrakul et al. (1976) studied this question.

synapsesocial.com/papers/6aacd8b01d70d673e7aab0e4 https://doi.org/10.3109/03630267609031023

View Full Paper

Ask AI

Bookmark

Implication

Comparative study shows globin chain synthesis ratios distinguish beta-plus from beta-zero thalassemia trait in Thai individuals, highlighting its utility for carrier classification.

B+-Thalassemia Trait: Hematologic and Hemoglobin Synthesis Studies

Discussion

Member takes

Implication

Key Points

Cite This Study

B+-Thalassemia Trait: Hematologic and Hemoglobin Synthesis Studies

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider