Reviewing HLA-B27's significance in spondyloarthritis reveals gaps in knowledge and mechanisms involved.
HLA-B27: a cornerstone in spondyloarthritis Nearly 50 years after its discovery as a major genetic risk factor for spondyloarthritis (SpA),1 the precise contribution of HLA-B27 to disease development and progression remains only partially understood. Proposed mechanisms include aberrant antigen presentation, misfolding-induced endoplasmic reticulum stress and modulation of innate immune responses.2.
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Beaufrère et al. (2025) studied this question.
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